When should men get a prostate exam? According to the American Cancer Society, men and people who were assigned male at birth (AMAB) should have their first prostate exam by age 50. If you have a family history of prostate cancer, you should consider having your first prostate exam at age 45. Don’t work out right before your PSA test. Vigorous exercise can cause a “bump” in PSA, with bicycle riding being the biggest culprit. Do tell your doctor if: You are taking Proscar or Avodart for BPH (benign prostate enlargement), or Propecia for hair loss. All three of these drugs can throw off your PSA level, making it seem lower than A9ZDmN4.