47. Freeze granulation Technology Developed and adopted by , Swedish Ceramic Institute (SCI). -By spraying a powder suspension into liquid nitrogen, the drops (granules) are instantaneously frozen. In a subsequent freeze- drying the granules are dried by sublimation of the ice without any segregation effects. Batch Reactor In the batch reactor, or BR the reactants are initially charged into a container, are well mixed, and are left to react for a certain period. The resultant mixture is then discharged. This is an unsteady-state operation where composition changes with time. 3. Plug flow reactor • In the PFR thr flow of fluid through the reactor These machines are new type fertilizer granulator, rotary drum granulator, rotary gear drum granulator, disc pan granulator, double roller granulator and flat die pelletizer. organic fertilizer granulation machine. Model : SXJZ – 1500. Installation Angle : 2°-2.5°. Capacity (t/h) : 6 – 8. Power (kw) : 110. The methods used for Pelletization are essentially the same as the granulation methods. The most widely used processes are extrusion and spheronization and solution or suspension layering, and The Glatt pelletizing container P20 for ideal spheronization of extrudates convinces by giving best spheronization results with very short residence times. The P20 is used with our 2 in 1 lab unit TMG, which allows granulation and pelletization in one table top unit. 10.13. Conclusion. Spheronization, granulation, pelletization, and agglomeration can be used to transfer powders or liquids to free-flowing granules with defined properties. This chapter provided practical examples of the particle formation process using operation principles of different types of equipment. 1.Low shear granulation. This is the classical method of wet granulation where the drug powder excipients are mixed in presence of binder solution, the resulting granules from the wetting technique are dried in a drier usually in a tray dryer. The dried granules are further processed to get desired size. Abstract and Figures. Melt granulation in a high-shear mixer is an alternative technique that converts fine powders into granules. The powder agglomeration is promoted by the addition of a low 3. INTRODUCTIONPellets are small free flowing, spherical particulate, manufactured by the agglomeration of fine powder or granules of bulk drugs along with excipients using the pelletization techniques. Pellets are small sized with size range of 0.5 -1.5mm. After being processed, pellets are usually filled in to hard gelatin capsules or We usually divide them into two main types, the dry and wet granulations. The dry pelletizing mainly use the powerful mechanical force of compression to make the pellets. Shunxin dry granulators are cost-effective and simple-operative, the granulation process can be cheap and fast. But not all the materials are suitable for high pressure process. k2eC.